Volume 56, Supplement
CONTENTS
December2009

The report on the 11th International Symposium on Exocrine Secretion 171
Kazuo Hosoi, Masataka Murakami, Ivana Novak
Plenary Lecture

Aquaporin water channels in transepithelial fluid transport 179
Lukmanee Tradtrantip, Masato Tajima, Lihua Li, AS Verkman
Keynote Lecture

Salivary gland and autoimmunity
185
Yoshio Hayashi, Rieko Arakaki, Naozumi Ishimaru
The salivary gland fluid secretion mechanism 192
Marcelo A Catalan, Tetsuji Nakamoto, James E Melvin
Regulation of Exocrine Glands by Taste Stimulation (Ajinomoto-sponsored Symposium)

Contribution of umami taste substances in human salivation during meal
197
Hisayuki Uneyama, Misako Kawai, Yuki Sekine-Hayakawa, Kunio Torii
Receptosecretory nature of type III cells in the taste bud 205
Sumio Yoshie
Taste, visceral information and exocrine reflexes with glutamate through umami receptors 209
Ana San Gabriel, Eiji Nakamura, Hisayuki Uneyama, Kunio Torii
Dietary monosodium glutamate enhances gastric secretion 218
Raisa Khropycheva, Hisayuki Uneyama, Kunio Torii, Vasiliy Zolotarev
Proteome analysis for rat saliva 224
Kiyotoshi Inenaga, Naoyuki Yamada, Reiko Yuji, Misako Kawai, Hisayuki Uneyama,Kentaro Ono,
Ei-ichiro Suzuki, Kunio Torii
Development, Regeneration, and Tissue Engineering of the Glandular Tissue

Branching morphogenesis in the fetal mouse submandibular gland is codependent on growth factors and
extracellular matrix
228
Edward W Gresik, Noriko Koyama, Toru Hayashi, Masanori Kashimata
Epithelial branching morphogenesis of salivary gland : exploration of new functional regulators 234
Takayoshi Sakai
Tube formation in developing mouse submandibular gland 239
Yohki Hieda
Salivary gland development : its mediation by a subtilisin-like proprotein convertase, PACE4 241
Tetsuya Akamatsu, Ahmad Azlina, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Kazuo Hosoi
Role of 6 integrin subunit in branching morphogenesis of fetal mouse submandibular gland : investigation by
mesenchyme-free epithelial culture system
247
Noriko Koyama, Toru Hayashi, Edward W Gresik, Masanori Kashimata
Detection of EGF-dependent microRNAs of the fetal mouse submandibular gland at embryonic day 13 250
Toru Hayashi, Noriko Koyama, Edward W Gresik, Masanori Kashimata
Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular
gland of mice
253
Nunuk Purwanti, Ahmad Azlina, Mileva R Karabasil, Takahiro Hasegawa, Chenjuan Yao,
Tetsuya Akamatsu, Kazuo Hosoi
Morphological study of the parotid duct in human fetuses with special emphasis on the relationship between
the buccinator muscle and the parotid duct
255
Kaori Amano, Hiroshi Moriyama, Kazuyuki Shimada, George Matsumura
Response of the Glandular Tissue to Environmental Stress and Neural/Hormonal Controle

Parotid acinar cells transiently change to duct-like cells during epithelial-mesenchymal transition 258
Junko Fujita-Yoshigaki, Bing Qi, Takanori Narita, Hiroshi Sugiya
E2F1-deficient NOD/SCID mice are an experimental model for dry mouth 260
Keitaro Satoh, Takanori Narita, Hikaru Matsui-Inohara, Tatsuro Ito, Hidenobu Senpuku, Hiroshi Sugiya
AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct 262
Elvin Odgaard, Helle A Praetorius, Jens Leipziger
Immunohistochemical study on the distribution and origin of GABAergic nerve terminals in the superior salivatory nucleus 264
Ayumi Matsushima, Hiroyuki Ichikawa, Masako Fujita, Yoshihiro Mitoh, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo
Cevimeline enhances the excitability of rat superior salivatory neurons 267
Hirotaka Ueda, Yoshihiro Mitoh, Hiroyuki Ichikawa, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo
Postnatal development of inhibitory synaptic transmission to superior salivatory neurons in rats 270
Yoshihiro Mitoh, Makoto Funahashi, Masako Fujita, Motoi Kobashi, Ryuji Matsuo
Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats 273
Ahmad Azlina, Xuefei Li, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Kazuo Hosoi
Parotid salivary secretion induced by stimulation of periodontal regions with toothbrush in humans 277
Kiyotoshi Inenaga, Tomohiro Inangaki, Ryuji Hosokawa, Kentaro Ono
Characterization of neurokinin A-evoked salivary secretion in the perfused rat submandibular gland 278
Takanori Narita, Bing Qi, Mika Fukano, Miwako Matsuki-Fukushima, Masataka Murakami, Hiroshi Sugiya
Characterization of neurokinin A-evoked salivary secretion in the perfused rat submandibular gland 278
Takanori Narita, Bing Qi, Mika Fukano, Miwako Matsuki-Fukushima, Masataka Murakami, Hiroshi Sugiya
Pilocarpine-induced salivary fluid secretion in the perfused submandibular gland of the rat 281
Bing Qi, Takanori Narita, Hiroshi Sugiya, Masataka Murakami
The thiol-oxidizing agent diamide reduces isoproterenol-stimulated amylase release in rat parotid acinar cells 284
Ming-Yu Guo, Takanori Narita, Bing Qi, Keitaro Satoh, Osamu Katsumata-Kato, Miwako Matsuki-Fukushima, Junko Fujita-Yoshigaki, Hiroshi Sugiya
Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice 287
Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata, Kazuo Hosoi
Hormone-induced granular convoluted tubule-like cells in mouse parotid gland 290
Shingo Kurabuchi, Takanori Matsuoka, Kazuo Hosoi
Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance 296
Toru Hosoi, Koichiro Ozawa
Aquaporin and Ion Channel/Transporter : Physiology and Disease

Anion secretory functions of acinar and intralobular duct cells in the rat parotid gland 299
Chikara Hirono, Makoto Sugita, Yoshiko Iwasa, Yoshiki Shiba
The essential role of luminal BK channels in distal colonic K+ secretion 301
Mads V Sorensen, Jens Leipziger
PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation 302
Heon Yung Gee, Hyun Woo Park, Kyung Hwan Kim, Min Goo Lee
Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease 306
Christoph Korbmacher
Glucose transport in interlobular ducts isolated from rat pancreas 308
Sachiko Futakuchi, Hiroshi Ishiguro, Satoru Naruse, Shigeru BH Ko, Kotoyo Fujiki, Akiko Yamamoto,
Miyuki Nakakuki, Ying Song, Martin C Steward, Takaharu Kondo, Hidemi Goto
The role of a group III AQP, AQP11 in intracellular organelle homeostasis 312
Kenichi Ishibashi, Shin Koike, Shintaro Kondo, Shigeki Hara, Yasuko Tanaka
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with
autoimmune pancreatitis
318
Shigeru BH Ko, Nobumasa Mizuno, Yasushi Yatabe, Toshiyuki Yoshikawa, Hiroshi Ishiguro,
Akiko Yamamoto, Sakiko Azuma, Satoru Naruse, Kenji Yamao, Shmuel Muallem, Hidemi Goto
Morpho-Physiological approach to the paracellular route for salivary secretion by isolated perfused submandibular gland 322
Masataka Murakami, Sadamitsu Hashimoto, Muxin Wei, Adrian E Hill
Apical Cl-/HCO3-exchanger stoichiometry in the modeling of HCO3-transport by pancreatic duct epithelium 325
Makoto Yamaguchi, Hiroshi Ishiguro, Martin Steward, Yoshiro Sohma, Akiko Yamamoto, Akito Shimouchi,
Takaharu Kondo
Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct 329
Andrew K Stewart, Boris E Shmukler, David H Vandorpe, Seth L Alper
Effects of Slc26a6 deletion and CFTR inhibition on HCO3 - secretion by mouse pancreatic duct 332
Ying Song, Hiroshi Ishiguro, Akiko Yamamoto, Chun Xiang Jin, Takaharu Kondo
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia 336
Dusik Kim, Martin C Steward
Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues 343
Chun Wang, Gang Chen, Junkang Jiang, Lianglin Qiu, Kazuo Hosoi, Chenjuan Yao
Electrophysiological properties of AQP6 in mouse parotid acinar cells 347
Hideki Ichikawa, Yoshiyuki Shibukawa, Yoshinori Sahara, Maki Tsumura, Bing Qi, Keitaro Satoh,
Takanori Narita, Sadamitsu Hashimoto, Yasunori Momose, Masakazu Tazaki, Masaki Shimono, Hiroshi Sugiya
Correlation between salivary secretion and salivary AQP5 levels in health and disease 350
Di Wang, Fusako Iwata, Masahiro Muraguchi, Keiko Ooga, Yasukazu Ohmoto, Masaaki Takai,
Toyoki Mori, Yasuko Ishikawa
K+ channels on resting duct cells from rat pancreas 354
Mikio Hayashi, Hiroko Matsuda
Signal Transduction of the Glandular Tissue

Extracellular purinergic signaling in pancreas 355
Ivana Novak, Kristian A Haanes, Mette R Hansen, Simon Krabbe, Susanne E Hede
Monitoring of IP3 dynamics during Ca2+ oscillations in HSY human parotid cell line with FRET-based IP3 biosensors 357
Akihiko Tanimura, Takao Morita, Akihiro Nezu, Yosuke Tojyo
Regulation of calcium entry in exocrine gland cells and other epithelial cells 362
James W Putney, Gary S Bird
Role of protein kinase C- in isoproterenol-induced amylase release in rat parotid acinar cells 368
Hiroshi Sugiya, Keitaro Satoh, Miwako Matsuki-Fukushima, Bing Qi, Ming-Yu Guo, Junko Fujita-Yoshigaki
PAR-2 receptor-induced effects on human eccrine sweat gland cells 371
Douglas L Bovell, Barbara Kofler, Roland Lang
Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts 375
Kentaro Ono, Tomohiro Inagaki, Taichi Iida, Ryuji Hosokawa, Kiyotoshi Inenaga
Ca2+ mobilization by nicotine through synaptic activation in rat parotid acini 376
Taichi Iida, Kentaro Ono, Tomohiro Inagaki, Ryuji Hosokawa, Kiyotoshi Inenaga
Spontaneous Ca2+ oscillations via purinergic receptors elicit transient cell swelling in rat parotid ducts 377
Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo
Store operated calcium entry in NIH-3T3 cells 381
Miwako Matsuki-Fukushima, Takuro Tomita, Gary S Bird, James W Putney, Jr
A novel Stim1-dependent, non-capacitative Ca2+ entry pathway is activated by B cell receptor stimulation and
depletion of Ca2+ stores
383
Takao Morita, Akihiko Tanimura, Yoshihiro Baba, Tomohiro Kurosaki, Yosuke Tojyo
Monitoring of IP3 dynamics during the mechanical stimulation-induced intra- and intercellular Ca2+ waves
in HSY human parotid cell line
388
Akihiro Nezu, Akihiko Tanimura, Takao Morita, Yosuke Tojyo
Membrane Trafficking and Molecular/Cellular Dynamics in the Exocrine Secretion

Separation of immature granules containing color dye from the rat parotid gland 391
Osamu Katsumata-Kato, Junko Fujita-Yoshigaki, Takanori Narita, Hiroshi Sugiya
Preliminary study of modification of serum albumin through paracellular pathway of rat submandibular gland 393
Tomoya Hayashi, Masataka Murakami, Seiichi Era
Morphological evidence of paracellular transport in perfused rat submandibular glands 395
Sadamitsu Hashimoto, Masataka Murakami
Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and
membrane trafficking
398
Mileva R Karabasil, Kwartarini Murdiastuti, Nunuk Purwanti, Ahmad Azlina, Purevjav Javkhlan,
Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Kazuo Hosoi

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